I'm watching Fushigi Yugi for the first time, and two events in particular came right on the heels of each other and just killed me.
[spoiler] The slaughter of Tamahome's family, and Yuiren's last few moments in her brother's arms...and Nuriko's sacrificial death. [/spoiler]
I don't know when I've cried that hard watching an anime before. The fact that I'm sick probably doesn't help my emotional stability any, but geez...